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Medical Devices industry

Closed System Transfer Device Market 2020 By Manufacturers, Regions, Type, And Application, Forecast To 2026

  • Code : SMI20836
  • Pages : 107
  • Date : Feb, 2020
  • Category : Medical Devices
  • Publisher : SMI
  • Format : SMI PPT FormatSMI PDF Format



 

Summary

The global Closed System Transfer Device Market is expected to witness a CAGR of xx% over the forecast period 2020-2026 and is expected to reach US$ xx million in 2026, from US$ xx million in 2019. 

A closed system transfer device, also called a closed system drug transfer unit or CSTD, is an airtight drug transfer device that mechanically restricts the passage of various environmental impurities into a closed system, usually a closed system transfer system, and the escape of harmful vapor or chemical concentrations out of the system. There are two types of closed system devices: those which have physically closed system seals, and those which are airtight but contain a biological seal. These devices have different capacities; for instance, biological closed systems are available in super strength and cryogenic strength. The types of biological seal devices include airtight plastic tubes and closed needle devices. The closed system transfer devices used in the manufacturing industries are closed needle devices, which are employed in on guard chemical reactions, and are very common in the manufacture of numerous types of chemicals and pharmaceutical products. These types of closed system transfer devices are often referred to as "On guard" or "Equasyielding" devices because they require a minimum of physical seal

Growing incidences of cancer and an increasing number of oncology drug approvals are driving growth of the closed system transfer devices market. According to the World Health Organization, cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Around 13% of cancers diagnosed in 2018 globally were attributed to carcinogenic infections, including Helicobacter pylori, human papillomavirus (HPV), hepatitis B virus, hepatitis C virus, and Epstein-Barr virus.

On the other hand, the high cost of closed system devices is expected to restrict growth of the market.

North America is expected to gain significant growth over the forecast period and this is attributed to the increasing novel drug approvals for the treatment of cancer. For instance, in May 2021, Amgen announced that the U.S. Food and Drug Administration (FDA) has approved LUMAKRAS™ (sotorasib) for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).

Key Developments:

In January 2018, Baxter International Inc. announced a U.S. launch of the Arisure Closed System Transfer device, which consists of several components that work together to help prevent contaminants from entering the intravenous (IV) medication delivery system and the escape of hazardous substances out of the system during drug preparation and administration.

The Closed System Transfer Device Market report highlights product development and growth strategies such as merger and acquisition adopted by market players along with SWOT Analysis, PEST and Porter’s Five Forces analyses of the Closed System Transfer Device Market, which highlight the strengths, weaknesses, opportunities, and commination of key companies. Moreover, the report offers two distinct market forecasts, one from the perspective of the producer and another from that of the consumer.

The various contributors involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers.

The Key Manufacturers covered in this Report:-

  • BD Medical, Inc
  • Equashield, LLC
  • ICU Medical, Inc
  • Teva Medical Ltd
  • Corvida Medical
  • ...

By the Product Type, the market is primarily segmented into:

  • Closed Vial Access Devices
  • Closed Syringe Safety Devices
  • Closed Bag/Line Access Devices

By Applications, the market is segmented into:

  • Passenger Vehicle
  • Commercial Vehicle

The Report covers the following Regions:

  • North America
    • United States
    • Canada
    • Mexico
  • Asia Pacific
    • China
    • Japan
    • South Korea
    • India
    • Australia
    • Indonesia
    • Thailand
    • Malaysia
    • Philippines
    • Vietnam
  • Europe
    • Germany
    • France
    • UK
    • Italy
    • Russia
  • Central & South America
    • Brazil
  • Middle East & Africa
    • Turkey
    • GCC Countries
    • Egypt
    • South Africa

Objective of the Closed System Transfer Device Market Report:

  • To assess the size of the market by value and volume
  • Analyze the Closed System Transfer Device Market in terms of regions and major countries
  • Highlight recent developments and trends in the market
  • Offer perceptive data regarding major market players in terms of key developments, strategies, and product portfolio
  • Determine share of the Closed System Transfer Device Market in terms of various segments such as by product type, application, and end-user
  • Offer accurate projection of the market for the forecast period using state-of –the-art tools and the current primary and secondary research approaches
  • Discuss major factors that impact growth of the Closed System Transfer Device Market

The Closed System Transfer Device Market engages the readers with all pivotal approaches to understand their position in the industry based on revenue or sales growth. The report efficiently evaluates the Closed System Transfer Device Market from various dimensions to deliver an end-product that is informative, elaborate, and accurate and includes detailed market segmentation, regional analysis, and competition in the market. The information in the report is backed by annual company reports, financial reports, press releases, regulatory databases, government documents, and statistical databases.

For the data information by region, company, type and application, 2019 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.

Key Stakeholders:

  • Material suppliers/wholesalers
  • Market Distributors/traders
  • Regulatory bodies
  • Research organizations, and consulting firms
  • Commercial research & developments (R&D)
  • Trade associations and industry bodies
  • Importers and exporters
  • End-use industries

Available Customizations:

Custom research is one of the most crucial components of the business strategy that helps an organization gain insight into specific business sector, aligned with its specific area of interest. Thus, SMI offers more accurate, pragmatic, and actionable information specifically tailored to suit your business needs.

 

Table of Contents

Executive Summary
1 Industry Overview of Closed System Transfer Device
1.1 Definition of Closed System Transfer Device
1.2 Closed System Transfer Device Segment by Type
1.2.1 Global Closed System Transfer Device Production Growth Rate Comparison by Types (2014-2025)
1.2.2 Closed Vial Access Devices
1.2.3 Closed Syringe Safety Devices
1.2.4 Closed Bag/Line Access Devices
1.3 Closed System Transfer Device Segment by Applications
1.3.1 Global Closed System Transfer Device Consumption Comparison by Applications (2014-2025)
1.3.2 Hospital
1.3.3 Clinic
1.4 Global Closed System Transfer Device Overall Market
1.4.1 Global Closed System Transfer Device Revenue (2014-2025)
1.4.2 Global Closed System Transfer Device Production (2014-2025)
1.4.3 North America Closed System Transfer Device Status and Prospect (2014-2025)
1.4.4 Europe Closed System Transfer Device Status and Prospect (2014-2025)
1.4.5 China Closed System Transfer Device Status and Prospect (2014-2025)
1.4.6 Japan Closed System Transfer Device Status and Prospect (2014-2025)
1.4.7 Southeast Asia Closed System Transfer Device Status and Prospect (2014-2025)
1.4.8 India Closed System Transfer Device Status and Prospect (2014-2025)

2 Manufacturing Cost Structure Analysis
2.1 Raw Material and Suppliers
2.2 Manufacturing Cost Structure Analysis of Closed System Transfer Device
2.3 Manufacturing Process Analysis of Closed System Transfer Device
2.4 Industry Chain Structure of Closed System Transfer Device

3 Development and Manufacturing Plants Analysis of Closed System Transfer Device
3.1 Capacity and Commercial Production Date
3.2 Global Closed System Transfer Device Manufacturing Plants Distribution
3.3 Major Manufacturers Technology Source and Market Position of Closed System Transfer Device
3.4 Recent Development and Expansion Plans

4 Key Figures of Major Manufacturers
4.1 Closed System Transfer Device Production and Capacity Analysis
4.2 Closed System Transfer Device Revenue Analysis
4.3 Closed System Transfer Device Price Analysis
4.4 Market Concentration Degree

5 Closed System Transfer Device Regional Market Analysis
5.1 Closed System Transfer Device Production by Regions
5.1.1 Global Closed System Transfer Device Production by Regions
5.1.2 Global Closed System Transfer Device Revenue by Regions
5.2 Closed System Transfer Device Consumption by Regions
5.3 North America Closed System Transfer Device Market Analysis
5.3.1 North America Closed System Transfer Device Production
5.3.2 North America Closed System Transfer Device Revenue
5.3.3 Key Manufacturers in North America
5.3.4 North America Closed System Transfer Device Import and Export
5.4 Europe Closed System Transfer Device Market Analysis
5.4.1 Europe Closed System Transfer Device Production
5.4.2 Europe Closed System Transfer Device Revenue
5.4.3 Key Manufacturers in Europe
5.4.4 Europe Closed System Transfer Device Import and Export
5.5 China Closed System Transfer Device Market Analysis
5.5.1 China Closed System Transfer Device Production
5.5.2 China Closed System Transfer Device Revenue
5.5.3 Key Manufacturers in China
5.5.4 China Closed System Transfer Device Import and Export
5.6 Japan Closed System Transfer Device Market Analysis
5.6.1 Japan Closed System Transfer Device Production
5.6.2 Japan Closed System Transfer Device Revenue
5.6.3 Key Manufacturers in Japan
5.6.4 Japan Closed System Transfer Device Import and Export
5.7 Southeast Asia Closed System Transfer Device Market Analysis
5.7.1 Southeast Asia Closed System Transfer Device Production
5.7.2 Southeast Asia Closed System Transfer Device Revenue
5.7.3 Key Manufacturers in Southeast Asia
5.7.4 Southeast Asia Closed System Transfer Device Import and Export
5.8 India Closed System Transfer Device Market Analysis
5.8.1 India Closed System Transfer Device Production
5.8.2 India Closed System Transfer Device Revenue
5.8.3 Key Manufacturers in India
5.8.4 India Closed System Transfer Device Import and Export

6 Closed System Transfer Device Segment Market Analysis (by Type)
6.1 Global Closed System Transfer Device Production by Type
6.2 Global Closed System Transfer Device Revenue by Type
6.3 Closed System Transfer Device Price by Type

7 Closed System Transfer Device Segment Market Analysis (by Application)
7.1 Global Closed System Transfer Device Consumption by Application
7.2 Global Closed System Transfer Device Consumption Market Share by Application (2014-2019)

8 Closed System Transfer Device Major Manufacturers Analysis
8.1 BD Medical, Inc
8.1.1 BD Medical, Inc Closed System Transfer Device Production Sites and Area Served
8.1.2 BD Medical, Inc Product Introduction, Application and Specification
8.1.3 BD Medical, Inc Closed System Transfer Device Production, Revenue, Ex-factory Price and Gross Margin (2014-2019)
8.1.4 Main Business and Markets Served
8.2 Equashield, LLC
8.2.1 Equashield, LLC Closed System Transfer Device Production Sites and Area Served
8.2.2 Equashield, LLC Product Introduction, Application and Specification
8.2.3 Equashield, LLC Closed System Transfer Device Production, Revenue, Ex-factory Price and Gross Margin (2014-2019)
8.2.4 Main Business and Markets Served
8.3 ICU Medical, Inc
8.3.1 ICU Medical, Inc Closed System Transfer Device Production Sites and Area Served
8.3.2 ICU Medical, Inc Product Introduction, Application and Specification
8.3.3 ICU Medical, Inc Closed System Transfer Device Production, Revenue, Ex-factory Price and Gross Margin (2014-2019)
8.3.4 Main Business and Markets Served
8.4 Teva Medical Ltd
8.4.1 Teva Medical Ltd Closed System Transfer Device Production Sites and Area Served
8.4.2 Teva Medical Ltd Product Introduction, Application and Specification
8.4.3 Teva Medical Ltd Closed System Transfer Device Production, Revenue, Ex-factory Price and Gross Margin (2014-2019)
8.4.4 Main Business and Markets Served
8.5 Corvida Medical
8.5.1 Corvida Medical Closed System Transfer Device Production Sites and Area Served
8.5.2 Corvida Medical Product Introduction, Application and Specification
8.5.3 Corvida Medical Closed System Transfer Device Production, Revenue, Ex-factory Price and Gross Margin (2014-2019)
8.5.4 Main Business and Markets Served

9 Development Trend of Analysis of Closed System Transfer Device Market
9.1 Global Closed System Transfer Device Market Trend Analysis
9.1.1 Global Closed System Transfer Device Market Size (Volume and Value) Forecast 2019-2025
9.2 Closed System Transfer Device Regional Market Trend
9.2.1 North America Closed System Transfer Device Forecast 2019-2025
9.2.2 Europe Closed System Transfer Device Forecast 2019-2025
9.2.3 China Closed System Transfer Device Forecast 2019-2025
9.2.4 Japan Closed System Transfer Device Forecast 2019-2025
9.2.5 Southeast Asia Closed System Transfer Device Forecast 2019-2025
9.2.6 India Closed System Transfer Device Forecast 2019-2025
9.3 Closed System Transfer Device Market Trend (Product Type)
9.4 Closed System Transfer Device Market Trend (Application)

10.1 Marketing Channel
10.1.1 Direct Marketing
10.1.2 Indirect Marketing
10.3 Closed System Transfer Device Customers

11 Market Dynamics
11.1 Market Trends
11.2 Opportunities
11.3 Market Drivers
11.4 Challenges
11.5 Influence Factors

12 Conclusion
13 Appendix
13.1 Methodology/Research Approach
13.1.1 Research Programs/Design
13.1.2 Market Size Estimation
13.1.3 Market Breakdown and Data Triangulation
13.2 Data Source
13.2.1 Secondary Sources
13.2.2 Primary Sources
13.3 Author List
13.4 Disclaimer

List of Table
List of Tables and Figures
Figure Picture of Closed System Transfer Device
Table Global Closed System Transfer Device Production (K Units) Growth Rate Comparison by Types (2014-2025)
Figure Global Closed System Transfer Device Production Market Share by Types in 2018
Figure Closed Vial Access Devices Product Picture
Figure Closed Syringe Safety Devices Product Picture
Figure Closed Bag/Line Access Devices Product Picture
Table Global Closed System Transfer Device Consumption (K Units) Comparison by Applications (2014-2025)
Figure Global Closed System Transfer Device Consumption Market Share by Applications in 2018
Figure Hospital
Figure Clinic
Figure Global Closed System Transfer Device Revenue (Million USD) (2014-2025)
Figure Global Closed System Transfer Device Production (K Units) (2014-2025)
Figure North America Closed System Transfer Device Market Size (Million USD) (2014-2025)
Figure Europe Closed System Transfer Device Market Size (Million USD) (2014-2025)
Figure China Closed System Transfer Device Market Size (Million USD) (2014-2025)
Figure Japan Closed System Transfer Device Market Size (Million USD) (2014-2025)
Figure Southeast Asia Closed System Transfer Device Market Size (Million USD) (2014-2025)
Figure India Closed System Transfer Device Market Size (Million USD) (2014-2025)
Table Closed System Transfer Device Raw Material and Suppliers
Table Manufacturing Cost Structure Analysis of Closed System Transfer Device in 2018
Figure Manufacturing Process Analysis of Closed System Transfer Device
Figure Industry Chain Structure of Closed System Transfer Device
Table Capacity and Commercial Production Date of Key Manufacturers
Table Global Closed System Transfer Device Manufacturing Plants Distribution
Table Closed System Transfer Device Major Manufacturers Technology Source and Market Position
Table Recent Development and Expansion Plans in Future
Table Closed System Transfer Device Capacity (K Units) of Major Manufacturers (2014-2019)
Table Closed System Transfer Device Production (K Units) of Major Manufacturers (2014-2019)
Table Closed System Transfer Device Production Market Share of Major Manufacturers (2014-2019)
Figure Closed System Transfer Device Production Share by Manufacturers in 2018
Table Closed System Transfer Device Revenue (Million US$) of Major Manufacturers (2014-2019)
Table Closed System Transfer Device Revenue Market Share of Major Manufacturers (2014-2019)
Figure Closed System Transfer Device Revenue Share by Manufacturers in 2018
Table Closed System Transfer Device Average Price (USD/Unit) of Major Manufacturers (2014-2019)
Table Global Manufacturers Market Concentration Ratio (CR5 and HHI)
Table Global Closed System Transfer Device Production by Regions 2014-2019 (K Units)
Table Global Closed System Transfer Device Production Market Share by Regions 2014-2019
Figure Global Closed System Transfer Device Production Market Share by Regions in 2018
Table Global Closed System Transfer Device Revenue by Regions 2014-2019 (Million USD)
Table Global Closed System Transfer Device Revenue Market Share by Regions 2014-2019
Figure Global Closed System Transfer Device Revenue Market Share by Regions in 2018
Table Global Closed System Transfer Device Consumption by Regions 2014-2019 (K Units)
Table Global Closed System Transfer Device Consumption Market Share by Regions 2014-2019
Figure North America Closed System Transfer Device Production Growth Rate 2014-2019 (K Units)
Figure North America Closed System Transfer Device Revenue Growth Rate 2014-2019 (Million USD)
Table North America Closed System Transfer Device Production, Consumption Import and Export (K Units)
Figure Europe Closed System Transfer Device Production Growth Rate 2014-2019 (K Units)
Figure Europe Closed System Transfer Device Revenue Growth Rate 2014-2019 (Million USD)
Table Europe Closed System Transfer Device Production, Consumption Import and Export (K Units)
Figure China Closed System Transfer Device Production Growth Rate 2014-2019 (K Units)
Figure China Closed System Transfer Device Revenue Growth Rate 2014-2019 (Million USD)
Table China Closed System Transfer Device Production, Consumption Import and Export (K Units)
Figure Japan Closed System Transfer Device Production Growth Rate 2014-2019 (K Units)
Figure Japan Closed System Transfer Device Revenue Growth Rate 2014-2019 (Million USD)
Table Japan Closed System Transfer Device Production, Consumption Import and Export (K Units)
Figure Southeast Asia Closed System Transfer Device Production Growth Rate 2014-2019 (K Units)
Figure Southeast Asia Closed System Transfer Device Revenue Growth Rate 2014-2019 (Million USD)
Table Southeast Asia Closed System Transfer Device Production, Consumption Import and Export (K Units)
Figure India Closed System Transfer Device Production Growth Rate 2014-2019 (K Units)
Figure India Closed System Transfer Device Revenue Growth Rate 2014-2019 (Million USD)
Table India Closed System Transfer Device Production, Consumption Import and Export (K Units)
Figure Global Consumption Closed System Transfer Device Market Share by Application (2014-2019)
Figure Global Value (Consumption) Closed System Transfer Device Market Share by Application (2014-2019)
Table BD Medical, Inc Closed System Transfer Device Production Sites and Area Served
Table BD Medical, Inc Closed System Transfer Device Product Introduction, Application and Specification
Table BD Medical, Inc Closed System Transfer Device Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019)
Table BD Medical, Inc Closed System Transfer Device Production Growth Rate (2014-2019)
Table BD Medical, Inc Closed System Transfer Device Production Market Share (2014-2019)
Figure BD Medical, Inc Closed System Transfer Device Revenue Market Share (2014-2019)
Table BD Medical, Inc Closed System Transfer Device Main Business and Markets Served
Table Equashield, LLC Closed System Transfer Device Production Sites and Area Served
Table Equashield, LLC Closed System Transfer Device Product Introduction, Application and Specification
Table Equashield, LLC Closed System Transfer Device Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019)
Table Equashield, LLC Closed System Transfer Device Production Growth Rate (2014-2019)
Table Equashield, LLC Closed System Transfer Device Production Market Share (2014-2019)
Figure Equashield, LLC Closed System Transfer Device Revenue Market Share (2014-2019)
Table Equashield, LLC Closed System Transfer Device Main Business and Markets Served
Table ICU Medical, Inc Closed System Transfer Device Production Sites and Area Served
Table ICU Medical, Inc Closed System Transfer Device Product Introduction, Application and Specification
Table ICU Medical, Inc Closed System Transfer Device Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019)
Table ICU Medical, Inc Closed System Transfer Device Production Growth Rate (2014-2019)
Table ICU Medical, Inc Closed System Transfer Device Production Market Share (2014-2019)
Figure ICU Medical, Inc Closed System Transfer Device Revenue Market Share (2014-2019)
Table ICU Medical, Inc Closed System Transfer Device Main Business and Markets Served
Table Teva Medical Ltd Closed System Transfer Device Production Sites and Area Served
Table Teva Medical Ltd Closed System Transfer Device Product Introduction, Application and Specification
Table Teva Medical Ltd Closed System Transfer Device Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019)
Table Teva Medical Ltd Closed System Transfer Device Production Growth Rate (2014-2019)
Table Teva Medical Ltd Closed System Transfer Device Production Market Share (2014-2019)
Figure Teva Medical Ltd Closed System Transfer Device Revenue Market Share (2014-2019)
Table Teva Medical Ltd Closed System Transfer Device Main Business and Markets Served
Table Corvida Medical Closed System Transfer Device Production Sites and Area Served
Table Corvida Medical Closed System Transfer Device Product Introduction, Application and Specification
Table Corvida Medical Closed System Transfer Device Production (K Units), Revenue (Million USD), Ex-factory Price (USD/Unit) and Gross Margin (2014-2019)
Table Corvida Medical Closed System Transfer Device Production Growth Rate (2014-2019)
Table Corvida Medical Closed System Transfer Device Production Market Share (2014-2019)
Figure Corvida Medical Closed System Transfer Device Revenue Market Share (2014-2019)
Table Corvida Medical Closed System Transfer Device Main Business and Markets Served
Figure Global Closed System Transfer Device Production (K Units) Growth Rate Forecast 2019-2025
Figure Global Closed System Transfer Device Revenue (Million USD) Growth Rate Forecast 2019-2025
Figure Global Closed System Transfer Device Sales Price (USD/Unit) Forecast 2019-2025
Figure North America Closed System Transfer Device Production Growth Rate Forecast 2019-2025 (K Units)
Figure North America Closed System Transfer Device Revenue Growth Rate Forecast 2019-2025 (Million USD)
Figure Europe Closed System Transfer Device Production Growth Rate Forecast 2019-2025 (K Units)
Figure Europe Closed System Transfer Device Revenue Growth Rate Forecast 2019-2025 (Million USD)
Figure China Closed System Transfer Device Production Growth Rate Forecast 2019-2025 (K Units)
Figure China Closed System Transfer Device Revenue Growth Rate Forecast 2019-2025 (Million USD)
Figure Japan Closed System Transfer Device Production Growth Rate Forecast 2019-2025 (K Units)
Figure Japan Closed System Transfer Device Revenue Growth Rate Forecast 2019-2025 (Million USD)
Figure Southeast Asia Closed System Transfer Device Production Growth Rate Forecast 2019-2025 (K Units)
Figure Southeast Asia Closed System Transfer Device Revenue Growth Rate Forecast 2019-2025 (Million USD)
Figure India Closed System Transfer Device Production Growth Rate Forecast 2019-2025 (K Units)
Figure India Closed System Transfer Device Revenue Growth Rate Forecast 2019-2025 (Million USD)
Table Global Production (K Units) of Closed System Transfer Device by Type (2019-2025)
Table Global Consumption (K Units) of Closed System Transfer Device by Application (2019-2025)
Table Closed System Transfer Device Distributors List
Table Closed System Transfer Device Customers List
Table Market Key Trends
Table Key Opportunities
Table Market Key Drivers
Table Key Challenges
Table Key Influence Factors
Table Research Programs/Design for This Report
Figure Bottom-up and Top-down Approaches for This Report
Figure Data Triangulation
Table Key Data Information from Secondary Sources
Table Key Data Information from Primary Sources

 



Frequently Asked Questions

The report efficiently evaluates the market from various dimensions to deliver an end-product that is informative, elaborate, and accurate and includes detailed market segmentation, regional analysis, and competitive landscape of the industry.
The report efficiently evaluates the current market size and provides industry forecast. The market was valued at xx Million US$ in 2019, and is expected to grow at a CAGR of xx% during the period 2020-2027.
The report efficiently evaluates the current market size and provides forecast for the industry in terms of Value (US$ Mn) and Volume (thousand ton / metric ton / cubic meter).
Market is segmented by Types, Applications, Technology, End-use Industries, and Regions.
The report presents the current market size, and market forecast, market opportunities, key drivers and restraints, regulatory scenario, industry trend, PESTLE analysis, PORTER’s analysis, new product approvals/launch, promotion and marketing initiatives, pricing analysis, export-import analysis, trade analysis, competitive landscape which help businesses in decision making. The analysis data is based on current and historical market trends which help in investment related decisions.
Custom research is crucial components of the business strategy which helps any organization to gain insight into specific business sector, aligned with specific area of interest. Thus, SMI offers more accurate, pragmatic, and actionable information specifically tailored to suit your business needs.

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