Aug, 2021 - By SMI
To fight age-related memory loss, new research focused on affecting brain structures called as perineuronal nets.
A new fascinating research project by United Kingdom scientists proposes an advanced way of treating loss of age-specific memory. Preclinical researches show a reduction in memory in older rats by distorting the structural composition in the brain called perineuronal networks. Perineuronal Networks (PNNs) are brain structures that enclose certain neuronal subsets that contribute to stabilization of neuronal transmission. They basically put a stop to the neuroplasticity observed during the first few years of life. While PNNs are crucial for an intelligent brain’s effective operation, they affect future nerve plasticity and ability to adapt by their very existence.
In a purpose of treating a range in illness from diabetes to post-traumatic stress disorder (PTSD), new study is going to begin to examine methods for modulating PNNs in adult brains. This recent study emerged from investigations that show the role of PNNs in the collection of memory. Before animal experiments, PNNs could become more capable of inhibiting with age, interfering with the development of new memories. Through modulation of the PNN function age-related lost memory could therefore be overturned potentially. Chondroitin sulphates are chemical substances capable of encouraging or inhibiting the functioning of PNNs. For example, the neuroplastic effect of chondroitin6-sulphate encourages neuroplasticity. The alignment of these two chemicals shifts as an individual age, and chondroitin6-sulphate levels fall. The scientists believe that this mechanism helps to decrease the influence of PNNs on age related memory.
The scientists examined the hypothesis and tampered the proportion of Chondroitin sulphate in adult rats. Chondroitin6-sulphate levels have been reestablished in PNNs and the findings have been remarkable. In the older rats memory deficits have been regained to those seen in the younger rats. Then, the scientists developed special mouse models for low chondroitin6-sulphate levels. These animals have shown very early signs of memory loss associated with age, confirming the role of chondoitin6-sulphate in memory. And when the mice had regained their chondoitin6-sulphate level of chondroitin, their memories enhanced as they were seen in healthy and young animals.
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